生物化學與分子生物學博導介紹
盛望
導師基本情況：
盛望，北京市特聘教授，生物醫學工程專業博士生導師。出生於1968年5月。1994年赴法國留學，並與1996年和2001年分別獲得里昂第一大學病毒學碩士和病毒博士學位。2001－2005年在加拿大多倫多大學進行博士後研修。2005年10月受聘北京工業大學生命科學與生物工程學院特聘教授。
主要研究方向：
1. 病毒在腫瘤的發生和發展中的作用，及抗病毒藥物和疫苗的'研究。
2. 幹細胞的分化。
課題基金：
獲得北京市自然科學基金和北京市教委基金的資助
部份論文：
1.Sheng W, Wang G, La Pierre DP, Wen J, Deng Z, Wong CK, Lee DY, Yang BB. (2006) Versican Mediates Mesenchymal-Epithelial Transition. Mol Biol Cell. Apr;17(4):2009-20.
2.Sheng W, Wang G, Wang Y, Liang J, Wen J, Zheng PS, Wu Y, Lee V, Slingerland J, Dumont D, Yang BB.. (2005) The roles of versican v1 and v2 isoforms in cell proliferation and apoptosis. Mol Biol Cell. Mar;16(3):1330-40.
3.Sheng W., Bouguermouh A., Bouzid M., Djennaoui D. and Ooka T. (2004) BAM HI DNA Fragment H-Polymorphism of Epstein-Barr Virus is Associated with the Mutations Present in an 89 BP Sequence Localized in EBNA2 Gene. Virus Genes. Aug; 29(1): 99-108.
4.Sheng W., Decaussin G., Ligout A. and Ooka T. (2003) BARF1 gene encoded by Epstein-Barr virus contributes to the malignant phenotype and to apoptosis resistance in Burkitt's lymphoma cell line Akata. Journal of Virology, 77(6): 3859-65.
5.Sheng W., Decaussin G., Sumner S. and Ooka T. (2001) N-terminal domain of BARF1 gene encoded by Epstein-Barr virus is essential for malignant transformation of rodent fibroblasts and activation of BCL-2. Oncogene 20 (10): 1176-1185.
6.Wu Y. Sheng W. Cheng L Dong H., Lee V., Lu F., Wong C.S., Lu W. Y. and Yang B.B (2004) Versican V1 isoform induces neuronal differentiation and promotes neurite outgrowth. Mol Biol Cell. May; 15(5): 2093-104.
7.Wu Y., Chen L., Cao L., Sheng W. and Yang B.B. (2004) Overexpression of the C-terminal PG-M/versican domain impairs growth of tumor cells by intervening in the interaction between epidermal growth factor receptor and beta1-integrin. J Cell Sci. May 1; 117(Pt 11): 2227-37.
8.Zheng P. S., Wen J. P., Ang L. C., Sheng W., Viloria-petit A., Wang Y., Wu Y. Kerbel R. S.and Yang B.B. (2004) Versican/PG-M G3 domain promotes tumor growth and angiogenesis. FASEB J. Apr; 18(6): 754-6.
9.Kiani C., Chen L., Lee V., Zheng P.S., Wu Y., Cao L., Adams M.E., Sheng W. and Yang B.B. (2003) Identification of the motifs and amino acids in aggrecan G1 and G2 domains that inhibit product secretion. Biochemistry. Jun 17; 42(23): 7226-37.
10.Guo X., Sheng W., Zhang Y. Malignant transformation of monkey kidney epithelial cell induced by EBV BARF1 gene and TPA. . (2001) Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. Dec; 15(4): 321-3. Chinese.
11.Bouzid M., Sheng W., Buisson M., Bouguermouh A., Morand P., Seigneurin JM and Ooka T. (1998) Different distribution of H1-H2 Epstein-Barr virus variant in oropharyngeal virus and in biopsies of Hodgkin's disease and in nasopharyngeal carcinoma from Algeria. International Journal of Cancer 77(2): 205-210.
聯絡方式：
Email: [email protected]
Tel: 010-67392780